The APC/C and CBP/p300 cooperate to regulate transcription and cell cycle progression

Article Abstract:

The anaphase promoting complex/cyclosome(APC/C) is a multicomponent E3 ubiquitin ligase which by targeting protein substrates for 26S proteasome-mediated degradation through ubiquitination coordinates the temporal progression of eukaryotic cells through mitosis and the subsequent G1 phase of the cell cycle. The results define discrete roles for the APC/C-CBP/p300 complexes in growth regulation.

Eukaryotes, Cell cycle, Ubiquitin-proteasome system

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Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis

Article Abstract:

The predictive value of molecular machine models that are involved in Caenorhabditis elegans early embryogenesis is examined. An integrated gene/protein network generated from functional relationship of protein interaction, expression profiling similarity and phenotypic profiling similarity is useful for the derivation of molecular machine models.

Phenotype, Phenotypes, Cell division

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BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3

Article Abstract:

Research reveals that BTB proteins are combination of the functional properties of Skp1 and F-box proteins in a single polypeptide. Data indicate that BTB-domain proteins serve as substrate-specific adaptors for Caenorhabditis elegans CUL-3 protein.

Physiological aspects, Cellular signal transduction, Protein metabolism, Ubiquitin

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