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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

Article Abstract:

Fasting hyperglycaemia and lowered expression of gluconeogenic enzymes arise in mice carrying a targeted disruption of the cyclic AMP response element binding (CREB) protein gene, or excessively expressing a dominant-negative CREB inhibitor. It is suggested that activation of PGC-1 by CREB in the liver plays a significant role in the pathogenesis of hepatic gluconeogenesis.

Author: Rudolph, Dorothea, Puigserver, Pere, Herzig, Stephan, Long, Fanxin, Jhala, Ulupi S., Hedrick, Susan, Quinn, Rebecca, Bauer, Anton, Schutz, Gunther, Yoon, Cliff, Spiegelman, Bruce, Montminy, Marc
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Liver, Glycogen

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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

Article Abstract:

Hormonal and energy-sensing pathways converge on the coactivator transducer of regulated CRE binding protein (CREB) activity 2 [TORC2] to modulate glucose output. The signals that activate AMPK attenuate the gluconeogenic programme by promoting TORC2 phosphorylation and blocking its nuclear accumulation and individuals with type 2 diabetes often exhibit fasting hyperglycaemia due to elevated gluconeogenesis.

Author: Hedrick, Susan, Montminy, Marc, Takemori, Hiroshi, Screaton, Robert A., Seung-Hoi Koo, Jeffries, Shawn, Ling Qi, Boussouar, Faycal, Flechner, Lawrence, Xinmin Zhang, Brindle, Paul
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Glucose metabolism, Binding proteins

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Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2

Article Abstract:

The effect of insulin during feeding in mice is studied. Results reveal that insulin modulates gluconeogenic gene expression during re-feeding by boosting the phosphorylation and ubiquitin-dependent degradation of TORC2.

Author: Hedrick, Susan, Montminy, Marc, Yi Liu, Seung-Hoi Koo, Yates, John, III, Dentin, Renaud, Vargas, Thomas, Heredia, Jose
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Gene expression, Phosphorylation, Insulin, Gluconeogenesis

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Subjects list: Research
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