The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

Article Abstract:

Oncogenes, genes involved in cancer formation, can cause cell transformation, which leads to uncontrolled growth of the cells and changes in the expression of other genes. During transformation, two factors, AP-1 and PEA3, which bind to DNA and regulate transcription (a process necessary for the synthesis of proteins from genes), are activated, and this allows the transcription of many different types of oncogenes, growth factors, and TPA (12-O-tetradecanoylphorbol-13-acetate), a factor that promotes tumor growth. The oncogenes Ets-1 and Ets-2 also encode transcription factors, which bind to DNA. The Ets-1 protein product interacts with two proto-oncogenes (the normal cellular counterparts of oncogenes), c-Fos and c-Jun, which are also components of transcription factors. The three proteins encoded by oncogenes may act together in the regulation of the growth of cells. (Consumer Summary produced by Reliance Medical Information, Inc.)

Identification and classification, Genetic transcription, Transcription (Genetics)

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

Article Abstract:

The development of an oncogenic state involves the accumulation of multiple independent mutations leading to deregulation of cell signaling pathways and their activation status can be reflected by identifiable gene expression signatures. Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of oncogenic pathway signatures to guide the use of targeted therapeutics.

Gene expression

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Oncogenomics and the development of new cancer therapies

Article Abstract:

The identification of mutations and alterations in cancer genome are accelerated by the use of automated sequencing technology and completion of the human genome. An international academic and pharmaceutical oncogenomics initiative is required to increase the understanding of this disease and to produce targeted therapies.

United States, Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Cancer & Cell R&D, Cancer research, Oncology, Experimental

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