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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

Article Abstract:

Mice lacking CXCR4, the cell surface receptor, were generated to elucidate the physiological functions of CXCR4. The functions of CXCR4 during embryogenesis were studied by developing embryos by in situ hybridization. CXCR4 and PBSF/SDF-1 were found to be responsible for the formation of a mature vascular system, supplying the gastrointestinal tract. The results suggested that CXCR4 is a main physiological receptor for PBSF/SDF-1.

Author: Nishikawa, Shin-ichi, Kataoka, Yuki, Yoshida, Nobuaki, Matsushima, Kouji, Kishimoto, Tadamitsu, Nagasawa, Takashi, Tachibana, Kazunobu, Hiorta, Seiichi, Iizasa, Hisahi, Yoshida, Hisahiro, Kawabat, Kenji, Kitamura, Yuhihiko
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Observations, Blood vessels, Cell membranes, Cell receptors, Plasma membranes

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

Article Abstract:

The transcription factor IRF-7 that is essential for the induction of type-I interferon (IFN-alpha/beta) genes via the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway is shown by using mice deficient in the Irf7 gene (Irf7(super -1-) mice). Details of the IFN-alpha/beta response that is critical to immunity against viruses are discussed.

Author: Ohba, Yusuke, Takaoka, Akinori, Yanai, Hideyuki, Negishi, Hideo, Honda, Kenya, Yoshida, Nobuaki, Asagiri, Masataka, Mizutani, Tatsuak, Sato, Mitsuharu, Shimada, Naoya, aniguchi, Tadatsugu
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Interferon, Immunity, Immunity (Physiology), Genetic research

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WAVE2 is required for directed cell migration and cardiovascular development

Article Abstract:

The physiological functions of WAVE2 by disruption of the WAVE2 gene in mice are presented. A genetic study on mice revealed that WAVE2 was expressed predominantly in vascular endothelial cells during embryogenesis.

Author: Suetsugu, Shiro, Yamazaki, Daisuke, Miki, Hiroaki, Kataoka, Yuki, Nishikawa, Shin-Ichi, Fujiwara, Takashi, Yoshida, Nobuaki, Tkenawa, Tadaomi
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Wiskott-Aldrich syndrome

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Subjects list: Research, United States
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