The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

Article Abstract:

Chemokine stromal cell-derived factor-1 (SDF-1) is a biological ligand for LESTR (leukocyte-expressed seven-transmembrane-domain receptor) which is an essential cofactor for entry of T-tropic primary HIV-1 and T-tropic laboratory-adapted strains into CD-4 cells. Thus, SDF-1 interferes with the use of the LESTR receptor that binds a CXC-chemokine, by HIV-1 and inhibits LESTR-mediated infection. However, SDF-1 fails to affect CCR-5-mediated infection by macrophage-tropic and dual-tropic primary HIV-1.

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The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

Article Abstract:

Chemokine stromal cell-derived factor-1 (SDF-1), is the natural ligand for LESTR (leukocyte-expressed seven-transmembrane-domain receptor)/fusin, with the receptor represented as CXCR-4. SDF-1 prevents T-cell-line-adapted HIV-1 infection at stages prior to reverse transcription and interferes with the use of the receptor and thus, with the interaction of the virus with CD4 cells. SDF-1 may prevent the emergence of syncytium-inducing viruses in combination with CC chemokines.

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CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

Article Abstract:

The central nervous system (CNS) can be infected by HIV-1, causing dementia associated with AIDS. A study indicates that microglia, the major target cells for HIV-1 infection in the CNS, express both CCR3 and CCR5. HIV-1 infection of microglia is inhibited by CCR3 ligand, eotaxin, and CCR5 ligand, MIP-1beta. The results show that both CCR3 and CCR5 facilitate efficient infection of the CNS by HIV-1.

Central nervous system, Cell receptors

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