Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation

Article Abstract:

Tissue-plasminogen activator (tPA) shows up as one of five immediate-early genes initiated by neural activity. Differential screening can identify the five genes activated by such processes as learning and memory, by screening clones from a library of complementary hippocampal DNA. The occurrence of tPA with neuronal activity, including epileptic seizures, suggests that tPA may contribute to activity-dependent plasticity of neurons by its involvement in structural changes.

Genetic aspects, Epilepsy, Tissue plasminogen activator

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Conservation of total synaptic weight through balanced synaptic depression and potentiation

Article Abstract:

Analysis of the mechanisms of memory show that it is reliant on changes in the strength of synapses. Here, molecular neuroscientists report the discovery of a homeostatic balance between plasticity and stability in synaptic activity in the amygdala portion of the brain. The article concludes that this mechanism compensates for long-term synaptic potentiation and depression, creating stability in synaptic weight.

Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Neurological R&D, Neurological research, Amygdala (Brain)

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Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus

Article Abstract:

A new study investigates the effects of detecting and storing new information on the persistence of long-term potentiation (LLP) in the hippocampus of rats. The research, in which rats are given a new, non-stressful environment to explore, shows that the processing of new information through the hippocampus may cause a redistribution of synaptic efficacy.

Physiological aspects, Learning, Neural transmission, Synaptic transmission, Hippocampus (Brain), Learning in animals, Animal learning

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