Too fast by mistake

Article Abstract:

A new genetic disorder in humans that accelerates ageing is analyzed using a mouse model. The mutation responsible for accelerated ageing has severely affected an enzyme called XPF-ERCC1 endonuclease, which is required for the repair of damage that distorts the DNA helix or the crosslinks between DNA strands.

United Kingdom, Gene mutations, Gene mutation, DNA repair

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

Article Abstract:

The possible causative effects of the ageing process have been intensely discussed, due to their low abundance and purely correlative connection with ageing. Approaches may allow us to design strategies to delay harmful consequences of naturally occurring somatic mitochondrial DNA (mtDNA).

Mitochondrial DNA

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Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

Article Abstract:

The study identifies Seladin-1 as a key mediator of Ras-induced senescence using a direct genetic screen. Ablation of Seladin-1 causes the bypass of Ras-induced senescence in rodent and human fibroblasts, and allows Ras to transform these cells.

Ras genes

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