Self-regulating synapses
Article Abstract:
It has been possible to identify a mechanism for the regulation of synapses in the brain that are responsive to the neurotransmitter glutamate. This mechanism of synaptic plasticity is based on changes in the composition and function of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Truncated TrkB-T1 mediates neutrophin-evoked calcium signalling in glia cells
Article Abstract:
Research demonstrates that astrocytes express truncated neurotrophin receptor TrkB, which respond to the ligand BDNF and release intracellular reserves of calcium. Data indicate that antisense TrkB messenger RNA reduces this BDNF-induced calcium signals in glia. Furthermore, the truncated receptor mediates inositol-1,4,5-triphosphate-dependent calcium release.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Neurotrophin-evoked rapid excitation through TrkB receptors
Article Abstract:
It is shown that neurotrophins evoke action potentials in central neurons. Brain derived neurotrophic factor (BDNF) and neurotrophin-4/5 were found to depolarize neurons just as rapidly as the neurotransmitter glutamate. Smaller responses were produced by neurotrophin-3. The neurotrophin-induced depolarization was due to activation of a sodium ion conductance, blocked by K-252a.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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