Tyrosine kinase activation through the extracellular domains of cytokine receptors

Article Abstract:

A study of the moleacular mechanism of cytokine-mediated signal transduction was investigated. The study protocol involved the use of chimeric receptors in which the extracellular and cytoplasmic domains of the erythropoietin receptor and of the interleukin receptor are linked in different combinations. The results indicate that the extracellular domains of cytokine receptors are involved in the transmission of distinct signals form cytokines for the activation of specific tyrosine kinases.

Interleukins, Protein tyrosine kinase, Protein-tyrosine kinase, Cell receptors

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Efficiency of signalling through cytokine receptors depends critically on receptor orientation

Article Abstract:

The haematopoietic cytokine erythropoeitin in humans is needed for the differentiation and proliferation of precursor cells into red blood cells. It binds and orientates two cell-surface erythropoietin receptors (EPORs) which lead to an intra-cellular phosphorylation cascade. Other erythropoietin-mimetic ligands that dimerize receptors can evoke cellular responses, although less efficiently.

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CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

Article Abstract:

It has been determined that CD45 suppresses Janus kinases and negatively controls cytokine receptor signalling.

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