United we sense...

Article Abstract:

It has been possible to characterize the relationships between receptor clustering, sensitivity and dynamic range in bacterial chemotaxis. This research suggests the presence of an additional type of adaptation in bacterial chemotaxis, with the degree of receptor clustering being determined by the concentration of ligand. The detailed molecular mechanism that explains such adaptation must still be identified, but the suggested dependence is in good alignment with observations on receptor function in other systems. This work brings research into bacterial chemotaxis into a new phase.

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Robustness in bacterial chemotaxis

Article Abstract:

Living cells respond to a variety of external stimuli via networks of interacting proteins. It is possible that reaction rate constants and enzyme concentrations must be precisely adjusted, or alternatively the main properties of the biochemical networks are robust. Chemotaxis of Escherichia coli was undertaken, to consider the variations of response and adaptation. Steady-state behaviour and adaptation show strong variations, but the precision of adaptation is robust, and does not later with the protein concentrations.

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Robustness in simple biochemical networks

Article Abstract:

Cells transfer and process information using complex networks of interacting molecular components, which are responsible for processes such as signal transduction and cell-cycle regulation. The sensitivity of the networks to biochemical changes is discussed and the concept of robustness is demonstrated with the use of a computer simulation of the chemotaxis pathway. It is concluded that the ability of the system to return to its basal state of response after agitation is robust.

Molecular biology, Genetic polymorphisms, Chemotaxonomy

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