VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

Article Abstract:

Vascular endothelial growth factor, VEGF 'knock in' mice, in which the hypoxia response element sequence in VEGF promoter was deleted, have an impaired potential to upregulate VEGF levels in conditions of stress, and these mice develop ALS like neuropathology. The results obtained, using behavioral and anatomical outcomes are that, an Equin infectious anemia virus (EIAV) lentiviral vector expressing VEGF induces a substantial increase in survival in a clinically relevant ALS model.

United States, Vascular endothelial growth factor, Amyotrophic lateral sclerosis

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Signalling silenced

Article Abstract:

The scientists discuss the mechanisms used by matrix metalloproteinase tissue inhibitor-2 protein to inhibit blood-vessel formation. They suggest that these mechanisms can be used for cancer treatment via cutting off its blood supply.

Belgium, Analysis, Prevention, Genetic aspects, Cardiovascular system, Circulatory system, Cancer, Cancer prevention, Metalloproteins, Genetic research, Blood proteins, Cardiovascular physiology

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Creating unique blood vessels

Article Abstract:

Issues are presented concerning the physiological processes governing the release of molecules by tissues suffering a shortage of oxygen. The function of these molecules in the growth of blood vessels is discussed.

Cardiovascular research

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