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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Viral dynamics in human immunodeficiency virus type 1 infection

Article Abstract:

Human immunodeficiency virus type-1 (HIV-1) replication within the body is investigated using experimental drugs which are powerful inhibitors of viral replication. The total life time of virus-producing cells and the plasma virus is very short. HIV-1 viraemia is retained in the body due to repeated de novo virus replication and infection along with fast cell turnover. This indicates that these viruses can be replaced by drug resistant variants within 14 days, restricting the action of drugs.

Author: Saag, Michael S., Nowak, Martin A., Johnson, Victoria A., Lifson, Jeffrey D., Bonhoeffer, Sebastian, Emini, Emilio A., Shaw, George M., Hahn, Beatrice H., Wei, Xiping, Ghosh, Sajal K., Taylor, Maria E., Deutsch, Paul
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
Virus replication

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Refolding the envelope

Article Abstract:

An important feature of HIV is the ability to thrive for a long time despite sustained and vigorous immune attack. The machinery behind HIV's remarkable evasion involves a protective membrane around the virus and an ordered, two-receptor mechanism of entry into cells.

Author: Kwong, Peter D.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Glycoproteins

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Antibody neutralization and escape by HIV-1

Article Abstract:

The role of neutralizing antibodies (Nab) in HIV-1 infection is unclear, but autologous Nab have been detected as early as 52 days after detection of HIV-specific antibodies. Discusses the research, accompanied by graphs, genetic data and tables.

Author: Saag, Michael S., Nowak, Martin A., Shaw, George M., Kappes, John C., Hahn, Beatrice H., Wei, Xiping, Decker, Julie M., Wang, Shuyl, Hui, Huxiong, Wu, Xiaoyun, Salazar-Gonzalez, Jesus F., Salazar, Maria G., Kilby, J. Michael, Komarova, Natalia L., Kwong, Peter D.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Physiological aspects

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Subjects list: HIV (Viruses), HIV, Research, HIV antibodies
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