c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption

Article Abstract:

The proto-oncogene c-Cbl is identified as a specific signalling pathway requiring expression of the c-Src gene for bone resorption. This was gleaned from the tyrosine-phosphorylation of c-Cbl in a Src-dependent manner in osteoclasts, where they colocalize on some vesicular structures. Both c-src and c-cbl antisense oligonucleotides inhibit in vitro bone resorption by osteoclast-like cells (OCLs). Moreover, tyrosine phosphorylation of c-CBL and the localization of c-Cbl-containing structures to the peripheral cytoskeleton are hampered in resorption-deficient c-src-OCLs and in wild-type OCLs treated with c-src antisense oligonucleotides.

Bones, Growth, Bone resorption, Signal peptides, Bone development

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The SIL gene is required for mouse embryonic axial development and left-right specification

Article Abstract:

Axial midline defects are found in mice embryos without the early-response gene SIL. These embryos also show randomized cardiac looping and a block in midline Sonic hedgehog signalling. It is possible that the early onset and extended duration of nodal, lefty-2 and Pitx2 expression across the whole right lateral-plate mesoderm is the reason why heart looping is randomized in SIL mutants but not in Shh and lefty-1 mutants. This may also be why other mouse, zebrafish and human mutants have variable co-occurrence and severity of left-right abnormalities.

Animal mutation

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