A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger
Article Abstract:
A study on the regulatory mechanism of the nonerythroid anion exchanger AE2 by the intracellular protons, reveals its high sensitivity to intracellular pH. The intracellular pH sensor is determined to be the four histidine residues inside the N-terminal, cytoplasmic domain of the pH-sensitive AE2 and AE3 exchangers. This domain is not found in the erythroid anion exchanger. The determined pH sensitivity AE2 and AE3 are consistent with their physiological activities. A new feedback mechanism is also proposed involving direct control of anion exchangers by intracellular protons.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Unique aspects of cytoplasmic male sterility and fertility restoration in Brassica napus
Article Abstract:
Cytoplasmic male sterility (CMS) is a common mitochondrially encoded trait leading to the failure of a plant to produce functional pollen. Two types of CMS, nap and pol, are endogenous to the oilseed rape species Brassica napus. Molecular and genetic analyses of the systems are summarized, revealing certain unique aspects of CMS and fertility restoration in Brassica. These may be significant in understanding the evolution of genes involved in the trait and their mechanisms.
Publication Name: The Journal of Heredity
Subject: Biological sciences
ISSN: 0022-1503
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Unlocking family secrets: K+ channel transmembrane domains
Article Abstract:
The transmembrane domain of a highly cation-selective ion channel is a 40 A-thick lipid bilayer membrane that contains the K+ channel (KcsA). The KcsA is a tetrameter of two transmembrane-spanning L helices which has been found to be highly-sensitive. It only allows a very specific subset of ions to transit the membrane to prevent cell disfunction and cell death. The sequence of high selectivity of KcsA is characterized by glycine, tyrosine, glycine residues.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form
- Abstracts: Organic solvent tolerance of Escherichia coli is independent of OmpF levels in the membrane. Effects of bacterial cell surface structures and hydrophobicity on attachment to activated sludge flocs
- Abstracts: Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint. Is allorecognition specificity in Hydractinia symbiolongicarpus controlled by a single gene?
- Abstracts: The discovery of metabolic co-operation. Search and discovery strategies for biotechnology: the paradigm shift
- Abstracts: The role of chemical communication in mate choice. Aggregation in Azospirillum brasilense: effects of chemical and physical factors and involvement of extracellular components