Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33

Article Abstract:

The autosomal dominant disorder familial eosinophilia has been mapped through research to the cytokine gene cluster. Using 312 separate polymorphic markers in a genomewide search, scientists found links for the disorder within the cytokine gene cluster. These were then subjected to resequencing. Results have ruled out mutation, but further research is needed to determine causation.

Author: Cargill, Michele, Tucker, Margaret A., Goldstein, Alisa M., Lin, Albert Y., Zimmerman, Peter A., Lander, Eric, Rioux, John D., Daly, Mark J., Green, Todd, Nutman, Thomas, Stone, Valerie A., Nguyen, Huy, Hudson, Thomas
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
United States, Genetic disorders, Cytokines, Eosinophilia, Human chromosome abnormalities

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Neuropathy target esterase gene mutations cause motor neuron disease

Article Abstract:

Several genome-wide analyses are conducted to explain the connection of the organophosphorus (OP) compounds with the motor neuron disease (MND). The MND is caused by the neuropathy target esterase (NTE) that is usually inhibited by the OP compounds.

Author: Leppert, Mark, Rainier, Shirley, Matsunami, Nori, Coon, Hilary, Bui, Melanie, Mark, Erin, Thomas, Donald, Tokarz, Debra, Lei Ming, Delaney, Colin, Richardson, Rudy J., Albers, James W., Stevens, Jeff, Fink, John K.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
Science & research, All Other Basic Organic Chemical Manufacturing, Industrial Organic Chemicals, Organophosphates, Organophosphorous Compounds, Gene mutations, Gene mutation, Genetic aspects, Esterases, Motor neuron disease, Organophosphorus compounds, Organic phosphorus compounds

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Subjects list: Health aspects, Research, Causes of
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