A plethora of lesion-replicating DNA polymerases
Article Abstract:
Recent findings relating to lesion-replicating DNA polymerases, of which there are many and which are key participants in translesion replication, are discussed. It appears that yeast, bacteria and humans accomplish tranlesion DNA synthesis by a common mechanism and in each case the main replicase for the organism, unable to bypass the lesion, dissociates from the template to leave a 3' primer terminus before the lesion. Then translesion replication is catalyzed by one of the DNA polymerases recently described.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA
Article Abstract:
Research to understand the process of derepression of localized mRNA shows the role of a specific elements in the 5' and 3' region of the oskar mRNA. Protein localization accounts for cell development and differentiation. When the mRNA reaches a specific domain it is derepressed and gene translation takes place. The process is discussed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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