CREB phosphorylation and dephosphorylation: a Ca2+- and stimulus duration-dependent switch for hippocampal gene expression
Article Abstract:
The signaling pathways that regulate the phosphorylation of cyclic adenosine monophosphate-responsive element binding protein (CREB) were analyzed in hippocampal neurons. CREB phosphorylation involving multiple Ca2+/calmodulin [CAM]-dependent kinases and phospho-CREB (pCREB) dephosphorylation was affected by synaptic activity in hippocampal neurons. Furthermore, nuclear protein phosphatase 1-mediated phosphorylation of nuclear pCREB is affected by the inactivation of CaN due to neuronal synaptic activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Thy-1, the enigmatic extrovert on the neuronal surface
Article Abstract:
Thy-1 is a glycoprotein with a characteristic immmunoglobulin variable domain fold attached to the plasma membrane by glycophosphatidylinositol anchors. It was the first lymphocyte surface antigen shown to be restricted to a functional subset of lymphocytes. Current research on the nervous system suggest that neuronal Thy-1 interacting with astrocyte restricts axonal growth. However, despite numerous findings on the nature of Thy-1, defining its functions remains to be accomplished.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Splicing regulation in neurons: tinkering with cell-specific control
Article Abstract:
Neurons are characterized by regulated alternative splicing events that result in protein structural changes. The neural specificity of the splicing activity promotes the selection of neuron-specific axon and differences in the level of repressor machineries. Moreover, the balance of regulation can be controlled from one cell type to another by differences in the interaction regulatory factors. Opposing signals also permit positive and negative control mechanisms to be overlaid.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation. Developmentally programmed assembly of higher order telomerase complexes with distinct biochemical and structural properties
- Abstracts: Statistical evaluation of age-at-onset anticipation: a new test and evaluation of its behavior in realistic applications
- Abstracts: Chromatid and chromosome type breakage-fusion-bridge cycles in wheat (Triticum aestivum L.) The polar-lethal Ovum mutant gene maps to the distal portion of mouse chromosome 11
- Abstracts: Biodegradation of ortho-cresol by a mixed culture of nitrate-reducing bacteria growing on toluene
- Abstracts: Transcription termination signals in the nin region of bacteriophage lambda: identification of rho-dependent termination regions