Cdc7 is required throughout the yeast S phase to activate replication origins

Article Abstract:

Recent research indicates Cdc7 kinase of Saccharomyces cerevisiae acts directly on individual replication origins, not only to trigger S phase. It seems requirements of early and late origins of Cdc7 are temporally, not quantitatively, different. Cdc7 activates early and late origins separately. Late origins require activity later in S phase to make replication initiation possible. Cdc7 is needed in the entire yeast S phase for activation of replication origins.

Molecular biology, Cell division, Protein kinases, Yeast fungi, Microbial biotechnology, Yeasts (Fungi)

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A role for recombination junctions in the segregation of mitochondrial DNA in yeast

Article Abstract:

In Saccharomyces cerevisiae, the MGT1 gene produces a recombination junction-resolving enzyme which is necessary for the segregation of genomes in the mixed type zygote. Removal of MGT1 gene decreases the number of mitochondrial DNA (mtDNA) molecules which are associated by recombination junctions and fewer chonriolites are formed. This change in the mtDNA structure probably causes the mitotic loss of mtDNA and the change in the segregation pattern.

Genetic aspects, Saccharomyces

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Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA

Article Abstract:

Mitochondrial DNA replicates via two different modes, according to a two-dimensional agarose gel electrophoresis of mouse mtDNA. The experiment detected two different intermediate classes, one of which had the properties of coupled leading- and lagging- strand replication products.

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