Chemokine receptors and HIV-1: an attractive pair?

Article Abstract:

A study proposes that receptor recognition can initiate the conformational changes leading to membrane fusion for the human immunodeficiency virus type 1 (HIV-1). It is therefore important to analyze the virus-receptor interaction to shed light on HIV-1 entry. The identification of several members of the chemokine receptor family as coreceptors required for HIV-1 infection is expected to have profound implications on HIV-1 pathogenesis research, therapeutics and small animal models development, and natural resistance to infection studies.

HIV (Viruses), HIV

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Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning

Article Abstract:

Two TGFbeta ligands called DPP and SCW and two type I TGFbeta receptors called TKV and SAX are required in the dorsal-ventral (DV) process that patterns the embryonic ectoderm of Drosophila. TKV and SCW mediate DPP and TKV signaling activities, respectively. In addition, a negative regulator of the DV patterning called SOG, selectively inhibits SCW action. The interactions among these components as determined by mRNA injection assays are discussed.

United States, Genetic aspects, Drosophila, Cell aggregation, Ligands, Ligands (Chemistry)

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