Tumorigenesis in mice carrying a truncating Brca1 mutation

Article Abstract:

Tumorigenesis is discussed in this research communication article based on what has been seen in mice carrying a truncating Brca1 mutation. Mutant mice carrying a modification in the Bra1 locus that eliminates the C-terminal half of the protein product have been generated. Results show that the missing BRCT and/or other domains are dispensable for survival, but required for tumor suppression, depending on genetic background Lymphomas were seen at all ages. Sarcomas and carcinomas were seen after long latency. Striking variability was seen in histopathology.

Statistical Data Included, Breast cancer

---

Mzf1 controls cell proliferation and tumorigenesis

Article Abstract:

Mzf1 has been found using research in knockout mice to control tumorigenesis and cell proliferation in hemopoietic cells. Mzf1 can function as a tumor/growth suppressor in the hemopoietic compartment.

Cell proliferation

---

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

Article Abstract:

Caspase 8 has been found to play a required role in T-cell homeostasis and in T-cell-mediated immunity. Mice with a targeted caspase 8 mutation restricted to the T-cell lineage were generated to study the role. Although normal thymocyte development was seen, so were a distinct decrease in the number of peripheral T-cells and impaired ex vivo T-cell response to activation stimuli . Death receptor-mediated apoptosis problems are linked to cancer and autoimmune disease.

Canada, Science & research, Cancer research, Autoimmune diseases, Cancer, Immunity, Immunity (Physiology), T cells, Homeostasis, Apoptosis

Similar abstracts:

• Abstracts: A critical role for amino-terminal glutamine/aspargine repeats in the formation and propagation of a yeast prion
• Abstracts: Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
• Abstracts: Combinatorial roles of the nuclear receptor corepressor in transcription and development. Identification of a regulated pathway for nuclear pre-mRNA turnover
• Abstracts: A Drosophila I(kappa)B kinase complex required for Relish cleavage and antibacterial immunity. The antibacterial arm of the Drosophila innate immune response requires an I(kappa)B kinase
• Abstracts: Assessment of GFP fluorescence in cells of Streptococcus gordonii under conditions of low pH and low oxygen concentration

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.