Embryonic patterning: to BMP or not to BMP, that is the question

Article Abstract:

The patterning of the ectoderm and mesoderm involves active BMP signaling on the ventral side and blocking BMP signaling on the dorsal side. This suggests that dorsal-ventral pattern formation may be a result of the presence or absence of BMP signaling. Further studies are recommended, especially on whether dorsal-ventral patterning of the endoderm also depends on BMP signaling as well as the nature of the molecule that initially induces mesoderm formation.

Vertebrates, Embryology, Animal embryology

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Social interaction and sensorimotor gating abnormalities in mice lacking Dv/1

Article Abstract:

Gene targeting was used to create mice completely deficient for Dv/1, a mouse homolog of the Drosphila segment polarity gene Dishevelled. The mice were viable, fertile and structurally normal, but showed reduced social interaction. Such mutants could therefore act as models for certain human psychiatric disorders.

Mental health, Observations, Mice, mutant strains, Mutant mice

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