Fine mapping of the split-hand/split-foot locus (SHFM3) at 10q24: evidence for anticipation and segregation distortion
Article Abstract:
The locus of SHFM3 on 10q24 has been narrowed to a region of about 2 cM between D10S1147 and D10S1240. SHFM3 is a gene associated with split-hand/split-foot malformation (SHFM, also called ectrodactyly). An extended Turkish family with 18 affected members in four generations was studied. Anticipation is suggested by several cases in which the phenotype is more severe in the offspring of a mildly affected parent. Evidence has been found of biased transmission from affected fathers of SHFM3 alleles to offspring.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Summary of second workshop on structural birth defects
Article Abstract:
Research on birth defects should focus on understanding the role that genes play in embryonic development. A list of research directions and technology resources discussed by attendees at a workshop on birth defects is included.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
A second acromelanistic allelomorph at the Albino locus of the Mongolian gerbil
Article Abstract:
The Mongolian gerbil was studied with a focus on a second acromelanistic allelomorph at the albino locus.
Publication Name: The Journal of Heredity
Subject: Biological sciences
ISSN: 0022-1503
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The making of a compound leaf: genetic manipulation of leaf architecture in tomato. The new bacterial cell biology: Moving parts and subcellular architecture
- Abstracts: Stable DNA replication: interplay between DNA replication, homologous recombination and transcription. Replication fork stalling at natural impediments
- Abstracts: A PCR technique based on the Hip1 interspersed repetitive sequence distinguishes cyanobacterial species and strains
- Abstracts: Memory and the brain: what's right and what's left? Micrasterias cells as model system for research on morphogenesis
- Abstracts: The Cold Spring Harbor Phage Course (1945-1970): a 50th anniversary remembrance. In remembrance: Norton B. Gilula (1944-2000)