Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development
Article Abstract:
In vasculogenesis growth factors act via endothelial cell-specific receptor tyrosine kinases. Vascular endothelial growth factors (VEGFs), ephrins and Angiopoietins have roles in vascular development, based on information from studies with knockout mice. The three different growth factor systems act in very different ways. VEGF and Angiopoietins seem to be complementary and coordinated in action. Ephrins seem to be important in later stages, but may be involved in formation of vessel primodia. Complementary expression patterns are important, but overlapping expression of ligands and receptors will likely in time be seen to be mechanistically important. Little is thusfar known about mechanisms of intracellular signaling in endothelial cells and about unique pathways. The available body of knowledge is reviewed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
Article Abstract:
Osteoprotegerin (OPG) plays a critical role in regulating postnatal bone mass. Experiments with OPG deficient mice also indicates a corelation between medial calcification of the aorta and renal arteries and the protein. This association between osteoporosis and arterial calcification opens possibilities for studying the impact of OPG regulation on these problems.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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