HSP101 functions as a specific translational regulatory protein whose activity is regulated by nutrient status
Article Abstract:
HSP101, a tobacco mosaic virus (TMV) 102-kD protein homologous to the HSP101/HSP104/ClpB heat shock protein family, acts as a specific translation-regulation protein. Its activity is controlled by nutrient status. RNA-binding and translation regulatory activites of HSP101 are not active in respiring cells or in those subject to limits on nutrients, but thermotolerance functions of the protein are unaffected in those circumstances. A protein necessary for specific translation enhancement of capped mRNAs has never been identified before nor has a translation-regulation function for a heat shock protein been reported. No functional distinction between the two eIF4G proteins found in eukaryotes has been made before. HSP101 binds the 68-nucleotide 5' leader which is partly responsible for efficient translation of TMV mRNA. The leader has no guanosine residues and has a central poly(CAA) region needed for stimulation of translation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Eph signaling is required for segmentation and differentiation of the somites
Article Abstract:
Segmentation of the paraxial mesoderm into parts lined up on the anteroposterior axis is an aspect of somitogenesis. Eph and ephrin are factors in signaling for patterning of presomitic mesoderm as well as in formating of somites. The role of certain proteins has been studied. Dominant negative forms of Eph receptors and ephrins were encoded. Eph signaling is essential for differentiation and segmentation of the somites.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
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