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Malignant glioma: genetics and biology of a grave matter

Article Abstract:

In this review the biology of the malignant brain tumors and its bearing in the development of a specific and an effective therapy are discussed. Data on histopathologic and genetic lesions of the lower-grade as well as highly aggressive glioma, glioblastoma are presented.

Author: Louis, David N., DePinho, Ronald A., Maher, Elizabeth A., Furnari, Frank B., Bachoo, Robert M., Rowitch, David H., Cavenee, Webster K.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
United States, Cancer research, Cancer, Histology, Pathological, Pathological histology

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Malignant astrotyic glioma: genetics, biology, and paths to treatment

Article Abstract:

A review highlighting the mechanisms underlying the genetics, biology and clinical behavior of glioblastoma and the scientific advances to improve the clinical course of this lethal disease is presented.

Author: Louis, David N., DePinho, Ronald A., Chin, Lynda, Hahn, William C., Furnari, Frank B., Bachoo, Robert M., Cavenee, Webster K., Ligon, Keith L., Fenton, Tim, Mukasa, Akitake, Stommel, Jayne M., Stegh, Alexander, Brennan, Cameron;
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
Physiological aspects, Cell cycle, Cancer invasiveness, Immunohistochemistry

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

Article Abstract:

The article discusses the identification and the significant functions of a PTEN-regulated STAT3 brain tumor suppressor pathway. The STAT3 pathway is found to behave differently in people with different genetic backgrounds and hence can be easily used for the development of a treatment for glioblastoma.

Author: DePinho, Ronald A., Levy, David E., Bachoo, Robert M., Bonni, Azad, Konopka, Genevieve, Puram, Sidharth V., Chan, Jennifer A., Mingjian J. You
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2008
Genetic transcription, Transcription (Genetics), Phosphorylation, Glioblastoma multiforme, Brain tumours

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Subjects list: Research, Analysis, Genetic aspects, Gliomas, Brain tumors
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