LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: Evidence of two distinct founding events beginning two millennia ago

Article Abstract:

Genotype data is collected to examine the hypotheses that patients with Parkinson disease who are of European and Middle Eastern-North African (MENA) origin share a single ancestral haplotype, and the most common ancestor lived in the 13th century. The genotyping of single-nucleotide-polymorphism markers in families with the leucine-rich repeat kinase 2 (LRRK2) G2019S reveals two haplotypes, in which families with haplotype 1 shared a common ancestor 2,250 years ago whereas those with haplotype 2 appeared to share a more recent founder.

Europe, Middle East, Genotype, Genotypes, Parkinson's disease, Parkinson disease

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Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol

Article Abstract:

The article analyses common single nucleotide polymorphisms (SNPs) in the genes and the effect of allelic variants in high-density lipoprotein (HDL) metabolism. The SNPs act in concert to influence plasma levels of HDL cholesterol.

Analysis, Cholesterol, HDL, HDL cholesterol lipoproteins, Human genome

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