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Biological sciences

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Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2

Article Abstract:

Ligand-dependent interaction of the glucocorticoid receptor (GR) with p53, a tumor supressor, has been found to enhance their degradation by Hdm2. A mechanistic basis has been found for the theory that GR and p53 act in opposing ways in the cell death/life decision. The mechanism of the joint inhibition in normal endothelial cells in response to hypoxia and mitomycin C was studied.

Physiological aspects, Cell death, Stress (Physiology), Endothelium, Ligands, Ligands (Chemistry)

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A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner

Article Abstract:

Formation of Spemann organizer is a very significant stage in dorsoventral axis determination of vertebrate development. A novel zebrafish homeobox gene, dharma, has been isolated. It can induce the organizer ectopically. For the first time a zygotic gene implicated in formation of an organizer-inducing center has been identified.

Fishes, Vertebrates, Cell differentiation, Cell interaction, Cell interactions, Embryology, Animal embryology

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A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene

Article Abstract:

A vital part of the endoderm formation pathway, CASANOVA, has been found through study of zebrafish to be encoded by a novel sox-related gene, cas. An HMG box-containing gene, 10J3, which is expressed in the endoderm, was isolated in a subtractive screen for Nodal-responsive genes for Tar-responsive genes.

Germany, Usage, Zebra fish, Zebra fishes, Animal mutation

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