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Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo

Article Abstract:

A study was conducted to show that expression of BMP-4 affects the regulation of lateral or dorsal mesodermal and neural genes and leads to the formation of a diminished neural plate. Ectopic expression of BMP-4 inhibits the formation of the dorsal and lateral mesoderm, while elimination of BMP-4 reverses the effect and alters the phenotype in the early embryo. These results suggest that expression of BMP-4 can be controlled to achieve desired effects.

Author: Ueno, Naoto, Kimelman, David, Suzuki, Atsushi, Schmidt, Jennifer E.
Publisher: Elsevier B.V.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
Genetic regulation, Morphogenesis, Xenopus, Embryology, Animal embryology

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Defects in limb, craniofacial, and thymic development in Jagged2 mutnt mice

Article Abstract:

Jagged2 gene and Notch signaling, which is a intercellular signaling mechanism, play an important part in the limb, thymic and craniofacial development of mice. Mutant mice without a domain of the Jagged2 protein had fatal defects in craniofacial morphogenesis. The mice also had fusion in the limbs and modified thymic morphology.

Author: Weinmaster, Gerry, Norton, Christine R., Gridley, Thomas, Yu Lan, Rulang Jiang, Chapman, Harry D., Shawber, Carrie, Serreze, David V.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
Genetic aspects, Cells (Biology), Morphology (Biology), Proteins, Cells, Extremities (Anatomy)

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