Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo

Article Abstract:

A study was conducted to show that expression of BMP-4 affects the regulation of lateral or dorsal mesodermal and neural genes and leads to the formation of a diminished neural plate. Ectopic expression of BMP-4 inhibits the formation of the dorsal and lateral mesoderm, while elimination of BMP-4 reverses the effect and alters the phenotype in the early embryo. These results suggest that expression of BMP-4 can be controlled to achieve desired effects.

Genetic regulation, Morphogenesis, Xenopus, Embryology, Animal embryology

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Defects in limb, craniofacial, and thymic development in Jagged2 mutnt mice

Article Abstract:

Jagged2 gene and Notch signaling, which is a intercellular signaling mechanism, play an important part in the limb, thymic and craniofacial development of mice. Mutant mice without a domain of the Jagged2 protein had fatal defects in craniofacial morphogenesis. The mice also had fusion in the limbs and modified thymic morphology.

Genetic aspects, Cells (Biology), Morphology (Biology), Proteins, Cells, Extremities (Anatomy)

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