STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo

Article Abstract:

The developmental switching of the mutually exclusive alternative splicing of the let-2 gene of Caenorhabditis elegans from exon 9 form in embryos to the exon 10 form in adults is studied. The usage of let-2 mutually exclusive exons through differential expression of green and red fluorescent protein identified the alternative splicing defective-2 gene, encoding a novel member of evolutionarily conserved STAR family of RNA-binding proteins.

Gene mutations, Gene mutation, Genetic aspects, Caenorhabditis elegans, Binding proteins

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Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene

Article Abstract:

A comparative genomics approach was undertaken to identify the proteins involved in ciliary and basal body biogenesis and function. A novel gene for Bardet-Biedl syndrome (BBS5) was identified with the study of human ciliation disorders.

Flagella (Microbiology), Flagella, Genetic research, Proteomics, Genomics

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