MAP kinase pathways in the yeast Saccharomyces cerevisiae
Article Abstract:
The five mitogen-activated protein kinase (MAPK) pathways observed in the yeast, Saccharomyces cerevisiae, were discussed. These pathways were the mating-pheromone response (MPR), cell integrity, filamentation-invasion, spore wall assembly and the high-osmolarity growth pathways. In the MPR pathway, Gbeta activation of the MPR cascade was influenced by downstream proteins, Ste5p and Ste20p. The MAPK cascade was necessary in signal transmission from the pheromone receptors in the plasma membranes to the nucleus. The pathway affected cell cycle arrest in reaction to pheromone.
Publication Name: Microbiology and Molecular Biology Reviews
Subject: Biological sciences
ISSN: 1092-2172
Year: 1998
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Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae
Article Abstract:
The cyclin-dependent protein kinase (CDK), Cdc28, of the Saccharomyces cerevisiae are discussed including its main regulators and effect of these regulators on transcription and proteolysis. Cdc28 activity affects the major events involved in yeast cell division and CDK activation necessitates cyclin binding and stimulatory phosphorylation. There are two broad classification of Cdc28 cyclins: the three G1 cyclins and the six B-type cyclins. The CDK inhibitors of Cdc28 are the substrates Far1, Sic1 and Cdc6. These substrates restricted the activities and complexes of Cdc28.
Publication Name: Microbiology and Molecular Biology Reviews
Subject: Biological sciences
ISSN: 1092-2172
Year: 1998
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Metabolism of sulfur amino acids in Saccharomyces cerevisiae
Article Abstract:
A large number of enzymes are required in the sulfur amino acid biosynthesis in Saccharomyces cerevisiae. The sulfur amino acid biosynthetic pathway in S. cerevisiae is strictly conrolled, in response to increases in the amount of intracellular S-adenosylmethionine (AdoMet), and the molecular mechanisms responsible for the regulation are discussed.
Publication Name: Microbiology and Molecular Biology Reviews
Subject: Biological sciences
ISSN: 1092-2172
Year: 1997
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