Molecular genetic analysis of remains of a 2,000-year-old human population in China--and its relevance for the origin of the modern Japanese population
Article Abstract:
Remains of a 2,000-year-old human Chinese population has relevance to the origin of the modern Japanese population. Molecular genetic analysis has been carried out using DNA from human remains excavated from the ancient Yixi site on the Shandong peninsula in China, where people lived about 2000 years ago. PCR amplification was used to determine nucleotide sequences for the mitochondrial D-loop regions of 414 mtDNA types from 1298 bodies. . Two indices were used to compare the ancient Yixi people with modern Asian and Pacific-area populations. The closest genetic relationship was between the ancient Yixi and the modern Taiwan Han Chinese. Yixi people are closer to Mongolians, mainland Japanese and Koreans than to Ainu and Ryukyu Japanese. They are less close to Yayoi and Jomon people, contemporaries and predecessors, respectively, in ancient Japan.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
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The challenges of psychopharmacogenetics
Article Abstract:
The challenges, history, and future of psychopharmacogenetics are discussed. The field is seen as the intersection of two rather young fields of study, pharmacogenetics and psychopharmacology, and just becoming recognized as a biomedical discipline in its own right. Panic disorder and the MAOA promoter, depression and the 5-HTT promoter and drug-metabolizing enzymes and receptor pharmacology are reviewed.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
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