Multiply antibiotic-resistant Streptococcus pneumoniae recovered from Spanish hospitals (1988-1994): novel major clones of serotypes 14, 19F and 15F

Article Abstract:

Spain has the highest incidence of multiply antibiotic-resistant isolates of Streptococcus pneumoniae. Of the prevalent serotypes, only three isolates have been characterized: serogroup 23, 6 and 14. Studies of 95 multiply antibiotic pneumococci isolated in Spain between 1988 and 1994 identified two new serogroups, 19 and 15, in addition to the previously characterized serogroups. Eighteen of the 24 isolates of serogroup 19 were members of a penicillin-resistant clone that is suggested to be a serotype 19F variant of serotype 23F, while the isolates of serotype 14 appeared to be members of an unknown penicillin-resistant clone.

Health aspects, Spain

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Serotype 14 variants of the Spanish penicillin-resistant serotype 9V clone of Streptococcus pneumoniae arose by large recombinational replacements of the cpsA-pbp1a region

Article Abstract:

Research was conducted to examine the serotype 14 variants of the Spanish penicillin-resistant serotype 9V clone of Streptococcus pneumoniae which have resulted from large recombinational replacements of the cpsA-pbp1a region. The relationship of the penicillin-resistant serotype 14 isolates to other penicillin-resistant pneumococci was established via multilocus sequence typing and were demonstrated to be serotype variants of the MPSp9V. The molecular basis of the emergence of the variants was elucidated through an analysis of their capsular locus and flanking regions.

Genetic recombination, Penicillin, Penicillins

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Molecular and genetic characterization of the capsule biosynthesis locus of Streptococcus pneumoniae type 23F

Article Abstract:

The region of the Streptococcus pneumoniae type 23F capsule locus between cps23fB and cps23fL has been amplified and cloned using long-range polymerase chain reaction. This section is 13 kb in size and consists of 12 new protein products. cps23f consists of 18 genes found in the pneumococcal chromosome between dexB and aliA. Putative functions have been assigned to the majority of cps23f genes based on similarity with known proteins and with reference to the structure of the type 23F repeat unit.

Nucleotide sequence, Base sequence, Polymerase chain reaction, Cloning, Biosynthesis, Gene amplification, Polysaccharides

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