New models in vogue for circadian clocks
Article Abstract:
Circadian clocks regulate a variety of activities in many organisms. The core of the clock produces the 24 hour regularity in activities in an oscillatory manner. Circadian clocks are controlled by the period (per) and the timeless genes in Drosophila and the frequency gene in Neurospora. In Drosophila, the expression of the per gene attains a peak during early night-time or late in the day. There is a time gap of 4 hours between the PER protein and PER mRNA which is essential for the perpetual oscillations. The delay mechanism in Drosophila occurs at the nuclear translocation level.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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The cry(super b) mutation identifies crytochrome as a Circadian photoreceptor in Drosophila
Article Abstract:
A new rhythm mutation was determined based on its elimination of per-regulated luciferase cycling in Drosophila. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness. The cry(super b) gene is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Behaviorally, cry(super b) displays poor synchronization to light-dark cycles in genetic backgrounds that induce external blindness.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Molecular bases for circadian clocks
Article Abstract:
Researchers have arrived at various explanations of the circadian cycles. Progress in understanding how internal circadian biological clocks work has been increasing exponentially and came to a crescendo during the latter half of 1998. The compiled information provided evidence for clocks within the animal/fungal clade of the known eukaryotes. The eruption of data has largely disproven previous assumptions regarding circadian biological clocks.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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