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Biological sciences

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Novel keratinase from Bacillus subtilis S14 exhibiting remarkable dehairing capabilities

Article Abstract:

The isolation of a keratinolytic-producing Bacillus subtilis strain and the characterization of the exceptional dehairing properties of its subtilisin-like keratinase are reported. It is found that this enzyme can be an alternative to sodium sulfide, the major pollutant from tanneries, and may completely replace it.

Protein kinases, Keratin

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Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome

Article Abstract:

The genetic modification of Bacillus subtilis for production of D-chiro-Inositol(DCI) from myo-inositol is reported. DCI is a drug candidate for the treatment of type 2 diabetes and polycystic ovary syndrome since it improves the efficiency with which the body uses insulin and also promotes ovulation.

Care and treatment, Bacterial genetics, Stein-Leventhal syndrome, Polycystic ovary syndrome

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A derepression system based on the Bacillus subtilis sporulation pathway offers dynamic control of heterologous gene expression

Article Abstract:

A novel system is designed to express and secrete heterologous proteins in Bacillus subtiltis by using a derepression system. The gene is placed under the control of the abrB promoter and Spo0A is controlled by using an isopropyl-[beta]-D-thiogalactopyranoside) (IPTG)-inducible promoter.

Analysis, Spores (Bacteria), Bacterial spores, Flow cytometry, Gene expression

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