Oligodendroblasts distinguished from O-2A glial progenitors by surface phenotype (O4(+)GalC(-)) and response to cytokines using signal transducer LIFR-beta
Article Abstract:
An immunopanning technique helps compare the differentiation capacity of G(sub D3)(super +)O4(-) and O4(+)GalC(-) progenitors that are separated directly from postnatal rat forebrain in cultures treated with several type-2 astrocyte-activating agents. G(sub D3)(super +)O4(-) cells are bipotential in the presence of ciliary neurotrophic factor, and differentiate into oligodendrocytes. Similar target specificity is exhibited by the astrocyte inducers leukemia inhibitory factor and oncostatin-M. Similar conditions do not induce astrocyte differentiation in O4(+)GalC(-) progenitors, which form myelinogenic oligodendrocytes. An overriding stimulus in fetal bovine serum is essential to induce differentiation into astrocytes.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
Article Abstract:
Glial cell line-derived neurotrophic factor (GDNF)R-alpha, a glycosylphosphatidylinositol-linked GDNF receptor, binds GDNF and mediates Ret protein tyrosine kinase activation. Neuro-2a cells expressing GDNFR-alpha increase autophosphorylation of Ret on treatment with GDNF. Treatment with a combination of a soluble form of the receptor and GDNF in cells without GDNFR-alpha produces Ret protein activation. GDNF activates Ret protein in cultured embryonic rat spinal cord motor neurons.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Eyespot development on butterfly wings: the focal signal
Article Abstract:
Results of several grafting experiments performed on the pupal wing epidermis of the nymphalid Bicyclus anynana suggest that variations in focal signal and not in epidermal response result in the appearance of a small eyespot in the anterior and a larger one in the posterior side of the dorsal forewing. A gradient mechanism explains the size variations between the anterior and the posterior eyespot.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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