P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers

Article Abstract:

The CG2 protein of Plasmodium falciparum has been postulated to be involved in chloroquine resistance in the malaria-causing parasite. A recent study has even claimed that this protein resembles a sodium-hydrogen exchanger (NHE). Sequence analysis of this protein reveals that it is not similar to NHE. The hydrophobic domains of CG2 are not characteristic of NHEs and the transport domain is not homologous to that of NHEs. Further, immunoelectronmicroscopy revealed that CG2 is not a membrane protein.

Physiological aspects, Drug resistance in microorganisms, Microbial drug resistance, Plasmodium falciparum

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Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections

Article Abstract:

Pathogenic microbes adapt in order to survive in their host for as long as possible and in order to survive through transmission to a new host. A single infecting organism can result in very diverse populations with a wide range of virulence properties. Pathogens that can carry out antigenic variation in this way show rapid mutability in certain chromosomal regions which have genes that perform a specialist role, and which have been named contingency genes.

Analysis, Infection, Mutation (Biology), Mutation, Antigens

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Complex polymorphisms in an 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa

Article Abstract:

Chloroquine resistance in Plasmodium flaciparum was first reported around 40 years ago, although the molecular mechanism of resistance has remained unknown. It has been found that chloroquine resistance can be partly reversed by verapamil. The mapping of the chloroquine-resistant locus to a 36 kb segment is reported, and the candidate gene required for the resistance mechanism, is identified.

Drug resistance

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