Polo-like kinases: a team that plays throughout mitosis

Article Abstract:

The polo-like kinases (plks) play a role in regulating centrosome behavior and regulate various stages in mitosis. Reconciling the observations about plk function in different organisms that at times seem to be disparate has been of interest. The plks act as a team throughout mitosis. Their carboxyl termini have three conserved regions in addition to a much-conserved amino-terminal catalytic domain. The function of serine-threonine kinase has been of much interest since it was found that it is highly conserved in humans and in yeasts and it was found that the Drosophila gene polo encoded it.

Observations, Evolution (Biology), Evolution, Mitosis, Protein kinases

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Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization

Article Abstract:

Research reveals that mutations in the Drosophila gene discs degenerate-4 (dd4) alters localization of gamma-tubulin ring complex to the centrosome but found dispersed in dd4 cells. Data show that although spindle formation occurs, cell cycle progression to anaphase stage is delayed or abolished.

United Kingdom, Statistical Data Included, Physiological aspects, Tubulins, Tubulin, Protein metabolism, Spindle (Cell division), Spindle (Cytoplasm)

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