Prolyl isomerases and nuclear function

Article Abstract:

Several types of enzyme characterize transcription factors that can be manipulated in a number of ways, including post-translational modification, cytoplasmic sequestration and inhibitory protein interaction. The DNA-binding activity of the c-Myb transcription factor can also be negatively determined by a stable relationship with Cyp40. The repeats of the N-terminal c-Myb DNA-binding domain are connected to the transactivation domain and the C-terminal negative regulatory domain.

DNA, Genetic regulation, Genetic transcription, Transcription (Genetics)

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LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction

Article Abstract:

Inactivation of LexA repressor is achieved by an intermolecular cleavage reaction to the enzymatic action of the C-terminal fragment of LexA, and is stimulated by the protein RecA which indirectly plays the role of a coprotease. The slow rate of Cl self-cleavage is attributed to the weak interaction between its cleavage site and the active site. The resistance of lambda CI dimers to cleavage is also responsible for the slow reaction rate.

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

Article Abstract:

Deletion of interleukin-1 beta (IL-1 beta)-converting enzyme (ICE) in mice blocks the lipopolysaccharide-activated release of IL-1 beta and IL-1 alpha. The mice also resist endotoxic shock in the absence of ICE. Apoptosis of macrophages and thymocytes in the ICE-deficient mice occurs normally and does not involve ICE functions.

Physiological aspects, Cell death, Interleukin-1

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