RAS is regulated by the let-7 MicroRNA family
Article Abstract:
Micro- RNAs are regulatory RNAs found in multicellular eukaryots, including humans and the overexpression of micro-84 RNA, belonging to the let-7 microRNA family, suppresses the multivulva phenotype of activating let-60/RAS (Reticular Activating System) mutations. The 3' untranslated regions of the human Reticular Activating system contain multiple LCSs, allowing let-7 to regulate RAS expression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development
Article Abstract:
The protein RSF1 may be similarly structured to the prototypical member of a unique family of general splicing repressors that inhibit SR proteins. Splicing factors of the SR protein family significantly affect gene splicing, and may be preventted from cooperating with the U1 nuclear ribonucleoprotein particle during binding pre-mRNA.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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miRNA, piRNA, siRNA - Kleine Wiener Ribonukleinsauren
Article Abstract:
The presentations by the scientists on RNA silencing which were held at IMBA, Vienna is discussed. Major themes included the characteristics, regulations and mechanisms of RNA silencing machineries and their components.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2007
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