Rac mediates growth factor-induced arachidonic acid release
Article Abstract:
The formation of stress fibers in response to epidermal growth factor (EGF) induced stress is controlled by Rac and Rho proteins and takes place through the lipoxygenase pathway of the arachidonic acid metabolism. Leukotrienes are needed for some EGF-induced changes in the cytoskeleton which include membrane ruffling followed by the formation of the stress fibers in Swiss 3T3 cells. Rac is necessary for the formation of leukotrienes which in turn activates Rho.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Chromosomal translocations in yeast induced by low levels of DNA polymerase: A model for chromosome fragile sites
Article Abstract:
Reduced levels of alpha-DNA polymerase result in greatly elevated frequencies of chromosome translocations and chromosome loss in the yeast Saccharomyces cerevisiae. It is demonstrated that a pair of Ty elements constitutes a preferred site for double-strand DNA breaks when DNA replication is compromised, analogous to the fragile sites observed in mammalian chromosomes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
Article Abstract:
The attachment of chromosomes to spindle microtubles is mediated mainly by kinetochores.Immunodepletion from and antibody addition to Exnopus egg extracts were used to show that CENP-E, the kinetochore-associated kinesin-like motor protein, is necessary for chromosome positioning at the metaphase plate.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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