Abstracts - faqs.org

Abstracts

Biological sciences

Search abstracts:
Abstracts » Biological sciences

Regulating the fate of mRNA: the control of cellular iron metabolism

Article Abstract:

Iron metabolism in mammalian cells is a coordinately regulated process involving the posttranscriptional regulation of transferrin receptor and ferritin proteins. Central to these processes are the iron-responsive element (IRE) and the IRE binding protein (IRE-BP), which modulate at least two genes in iron metabolism at the translational level and at the level of mRNA degradation. Further molecular aspects of the IRE-BP system are discussed, and a working model for the regulation of IRE-BP is presented.

Author: Klausner, Richard D., Rouault, Tracey A., Harford, Joe B.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
Physiological aspects, Genetic regulation, Cellular control mechanisms, Cell regulation, Messenger RNA, Iron, Iron (Metal)

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Identification of an intestinal heme transporter

Article Abstract:

A subtractive hybridization approach is utilized to isolate a heme transporter from duodenum by taking advantage of the intestinal gradient for heme absorption. A membrane protein named HCP1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner.

Author: Anderson, Gregory J., Shayeghi, Majid, Hider, Robert C., Frazer, David M., Latunde-Dada, Gladys O., McCann, Fiona E., Oakhill, Jonathan S., Warley, Alice, Vulpe, Christopher D., Laftah, Abas H., Khan, Yasmin, Simpson, Robert J., Takeuchi, Ken, Halliday, Neil, McKie, Andrew T.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Cell research, Cytological research, Cell hybridization

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


The intestinal heme transporter revealed

Article Abstract:

A heme transporter that is expressed in the apical region of epithelial cells in the mouse duodenum is described. The transporter, called as heme carrier protein 1 (HCP1) is highly conserved and is part of a larger family of transporters known as the major facilitator super-family (MFS).

Author: Rouault, Tracey A.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Epithelial cells

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, United States, Hemoproteins, Duodenum
Similar abstracts:
  • Abstracts: More than the sum of their parts: on the evolution of proteins from peptides. How to tweak a beak: Molecular techniques for studying the evolution of size and shape in Darwin's finches and other birds
  • Abstracts: Linking chordate gene networks to cellular behavior in ascidians. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field
  • Abstracts: Premeiotic clusters of mutation and the cost of natural selection. Modes of Selection and Recombination Response in Drosophila melanogaster
  • Abstracts: Transcriptional checkpoints determining the fate of male germ cells. Homeobox galore: When reproduction goes RHOX and Roll
  • Abstracts: A phosphatase controls the fate of receptor-regulated Smads. Phy tunes: Phosphorylation status and phytochrome-mediated signaling
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.