Regulating the fate of mRNA: the control of cellular iron metabolism

Article Abstract:

Iron metabolism in mammalian cells is a coordinately regulated process involving the posttranscriptional regulation of transferrin receptor and ferritin proteins. Central to these processes are the iron-responsive element (IRE) and the IRE binding protein (IRE-BP), which modulate at least two genes in iron metabolism at the translational level and at the level of mRNA degradation. Further molecular aspects of the IRE-BP system are discussed, and a working model for the regulation of IRE-BP is presented.

Physiological aspects, Genetic regulation, Cellular control mechanisms, Cell regulation, Messenger RNA, Iron, Iron (Metal)

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Identification of an intestinal heme transporter

Article Abstract:

A subtractive hybridization approach is utilized to isolate a heme transporter from duodenum by taking advantage of the intestinal gradient for heme absorption. A membrane protein named HCP1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner.

Cell research, Cytological research, Cell hybridization

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The intestinal heme transporter revealed

Article Abstract:

A heme transporter that is expressed in the apical region of epithelial cells in the mouse duodenum is described. The transporter, called as heme carrier protein 1 (HCP1) is highly conserved and is part of a larger family of transporters known as the major facilitator super-family (MFS).

Epithelial cells

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