Regulatory divergence modifies limb length between mammals

Article Abstract:

The variation within populations caused by the differences in DNA sequences regulating gene expression is examined. Findings reveal that mutations accumulated in pre-existing noncoding regulatory sequences within a population are responsible for variation in the evolution of morphological differences between species.

Analysis, Nucleotide sequence, Base sequence, Evolution (Biology), Gene expression, Evolution, Mutation (Biology), Mutation, Population genetics

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Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis

Article Abstract:

Ovarian cancer 1 (Ovca1) is a tumor suppresser that acts as a positive regulator for cell cycle progression. Evolution of ovarian, breast and other tumor phenotypes attributed to the coordinated loss of OVCA1 and p53 on the human Chromosome 17.

Care and treatment, Ovarian cancer

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BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning

Article Abstract:

A study examines the role of bone morphogenetic protein receptor in the mesenchyme of a vertebrate limb.

United States, Growth, Control, Bone morphogenetic proteins, Company growth, Muscular dystrophy

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