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Regulatory divergence modifies limb length between mammals

Article Abstract:

The variation within populations caused by the differences in DNA sequences regulating gene expression is examined. Findings reveal that mutations accumulated in pre-existing noncoding regulatory sequences within a population are responsible for variation in the evolution of morphological differences between species.

Author: Martin, James F., Green, Eric D., Behringer, Richard R., Ying Wang, Cretekos, Chris J., Rasweiler, John J., IV
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2008
Analysis, Nucleotide sequence, Base sequence, Evolution (Biology), Gene expression, Evolution, Mutation (Biology), Mutation, Population genetics

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Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis

Article Abstract:

Ovarian cancer 1 (Ovca1) is a tumor suppresser that acts as a positive regulator for cell cycle progression. Evolution of ovarian, breast and other tumor phenotypes attributed to the coordinated loss of OVCA1 and p53 on the human Chromosome 17.

Author: Behringer, Richard R., Chen, Chun-Ming
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
Care and treatment, Ovarian cancer

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BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning

Article Abstract:

A study examines the role of bone morphogenetic protein receptor in the mesenchyme of a vertebrate limb.

Author: Wang, Ying, Martin, James F., Mishina, Yuji, Behringer, Richard R., Ovchinnikov, Dmitry A., Selever, Jennifer, Chen, You-Tzung
Publisher: Elsevier B.V.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
United States, Growth, Control, Bone morphogenetic proteins, Company growth, Muscular dystrophy

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Subjects list: Research
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