Role of macrophages in peripheral nerve degeneration and repair
Article Abstract:
Specific antibody staining show that Wallerian degeneration and nerve regeneration is mediated by macrophages. Nerve injury causes release of a chemotactic signal from disintegrating axons to recruit monocytes which remove axonal and myelin debris by phagocytosis and the action of proteases and reactive oxygen metabolites. Schwann cells then proliferate as a result of series of monocytic growth-promoting factors and cytokines. The same mechanism may also occur in the brain and spinal cord but the process is poor and slower as compared to peripheral nervous system due to the poor monocyte recruitment in the central nervous sytem.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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Macrophages in resistance to candidiasis
Article Abstract:
Macrophages act as effector cells to the fungus Candida albicans through the use of opsonin-dependent and opsonin-independent mechanisms. Mononuclear phagocytic cells are able to destroy C. albicans when they are grouped together, particularly when activated with cytokines. Further research is required to establish why and how mononuclear phagocytic cells are resistant to infection at some sites and not others.
Publication Name: Microbiology and Molecular Biology Reviews
Subject: Biological sciences
ISSN: 1092-2172
Year: 1997
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Development of myelin Mosaicism in the optic nerve of heterozygotes of the X-linked myelin-deficient (md) rat mutant
Article Abstract:
Female heterozygotes of the X-linked myelin deficient (md) rat trait revealed a level of mosaic patterns of myelination of the optic nerves that is not seen in other areas of the central nervous system. Light microscopy was used to analyze the 235 optic nerves from female rats with ages ranging from 3 weeks to 2 years.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
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