Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium
Article Abstract:
A study was carried out to identify transcriptional basis for the inhibition of chondrocyte maturation by perichondrium where Runx2 controls expression of fgf18, a negative regulator of chondrocyte maturation. It was shown that Runx2 fulfills antagonistic functions during chondrogenesis, which may help regulate bone formation.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
Gene expression, Genetic research, Cartilage cells
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Cbfbeta regulates Runx2 function isoform-dependently in postnatal bone development
Article Abstract:
Using a study on mice, the roles of transcription factors, Runx2 and Cbfbeta, in embryonic skeletal development are analyzed.
Publisher: Elsevier B.V.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
Japan, Bones, Embryology, Experimental, Embryological research, DNA binding proteins, Bone development, Rodents as laboratory animals, Laboratory rodents
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
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Subjects list: Research
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