A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities

Article Abstract:

Polycomb response elements (PREs) are specific cis-regulatory sequences needed for transcriptional repression of HOX and other target genes by Polycomb group (PcG) proteins. Pho protein complexes of PcG were purified from Drosophila embryos to gain insight into its function and it was found that Pho exists in two distinct protein assemblies, and results show that Pho-repressive complex (PhoRC) combines DNA-targeting activity with a unique modified histone-binding activity.

Histones, Genetic transcription, Transcription (Genetics), Protein binding

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Drosophila UNR is required for translational repression of male-specific lethal 2 mRNA during regulation of X-chromosome dosage compensation

Article Abstract:

A study was conducted to show that (dUNR) Drosophila upstream of N-ras is required for translational repression of (msl-2) male-specific lethal 2 mRNA. The results indicate that although UNR is present in both male and female flies, binding of SXL (sex-lethal) to uridine-rich sequences in the 3' untranslated region (UTR) of msl-2 mRNA recruits UNR to adjacent regulatory sequences, thereby conferring a sex-specific function to UNR.

Genetic translation, Translation (Genetics), Lethal mutation

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