Association of the transcriptional corepressor TIF1 beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation

Article Abstract:

A study was conducted, which engineered a modified embryonal carcinoma F9 cell line (TIF1 beta(super HP1box/-)) expressing a mutated TIF1 beta protein (TIF1 beta(super HP1box)) unable to interact with HP1proteins. Collectively the data demonstrated that the interaction between TIF beta and HP1 proteins is essential for progression through differentiation by regulating the expression of endoderm differentiation master player.

Canada, Cancer, Proteins, Properties, Carcinoma

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C-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

Article Abstract:

Conditional gene targeting, as well as a gain-of-function approach, is used to investigate the role of c-Myc during adult hematopoiesis. Analysis of the data indicate that c-Myc, in addition to being essential for proliferation of lineage-committed hematopoietic cells in vivo, plays an unexpected role in controlling the balance between HSC self-renewal and differentiation.

Hematopoietic stem cells, Gene targeting

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