Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking

Article Abstract:

Structural basis for interaction of FxFG nucleoporin repeats and importin-beta are discussed relative to nuclear trafficking. The crystal structure of a a complex of importin-beta residues 1-422 and five FxFG nucleoporin repeats form Nsp1p has been studied. RanGTP may release importin-beta from FxFG nucleoporins by generating a conformational change that alters the structure of the FxFG binding site.

United Kingdom, Carrier proteins, Transport proteins, Binding sites (Biochemistry), Active sites (Biochemistry), Cell nuclei, Cell nucleus, Nuclear membranes, Nuclear membrane

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Repression: targeting the heart of the matter

Article Abstract:

Transcriptional repression, which is essential to the precise control of gene expression, is discussed in this review article which focuses on repressors that affect formation of the initiation complex. Several functionally distinct general repressors of transcription are analyzed. Topics include the relationship between nucleosomes and general repressors, the Dr1/Drap1 complex, Mot1, the Srb10/Srb11 complex, the Not complexes, and multifunctional repressors.

Chile, Statistical Data Included, Genetic aspects, Chromatin, Gene expression, Genetic transcription, Transcription (Genetics), Yeast, Yeast (Food product)

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