Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex

Article Abstract:

The biochemical purification of Toca-1 (transducer of Cdc42-dependent actin assembly) as an essential component of the Cdc42 pathway is described. It is found that in this model, activated Cdc42 interacts with both Toca-1 and the N-WASP-WIP complex, and these interactions lead to the activation of N-WASP, which in turn stimulates actin nucleation through the Arp2/3 complex.

Author: Kirschner, Marc W., Gygi, Steven P., Hsin-Yi Henry H, Rohatgi, Rajat, Hsin-Yi Henry Ho, Jiaxu Li
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
Actin, Nucleation, Nucleation (Chemistry)

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Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs

Article Abstract:

Researchers conducted tests to show that Rdp1 is associated with two proteins, Hrr1, which is an RNA helicase, as well as with Cid12, which is a member of the polyA polymerase family. The findings suggest that there is a physical as well as a functional link between Rdp1 and RITS.

Author: Gygi, Steven P., Gerber, Scott A., Moazed, Danesh, Motamedi, Mohammad, Verdel, Andre, Colmenares, Serafin U.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
RNA polymerases, RNA interference

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Subjects list: Research
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