XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

Article Abstract:

The mammalian HMG box factors Tcf-1 and Lef-1 have the maternally expressed Xenopus homolog XTcf-3, whose N-terminus binds to beta-catenin. However, previous studies have failed to fully explain the biological activities of beta-catenin. A study showing that nuclear translocation of beta-catenin results from the microinjection of XTcf-3 in embryos indicates that signaling by beta-catenin involves complete formation with XTcf-3 and the nuclear translocation and activation of specific XTcf-3 target genes.

Genetic aspects, Homology (Biology), Xenopus

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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

Article Abstract:

dTCF, a Drosophila gene which is a member of the family of transcription factors (T cell factor) was cloned and analyzed functionally using in situ hybridization, yeast two-hybrid and enzyme assays. The results confirmed that dTCF binds a canonical TCF DNA motif and interacts with beta-catenin homolog Armadillo. It was also found that dTCF forms a complex with Armadillo through which they act as bipartite transcription factor involved in the Wingless signaling pathway.

Methods, Usage, In situ hybridization, Cloning, Drosophila, Enzymatic analysis

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Transcription factor target practice

Article Abstract:

Different ways of identifying direct targets of transcription factors and their corresponding regulatory sequences in the genome are studied. These studies provide an efficient way to decipher regulatory networks.

United States, Science & research, Nucleotide sequencing

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