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XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

Article Abstract:

The mammalian HMG box factors Tcf-1 and Lef-1 have the maternally expressed Xenopus homolog XTcf-3, whose N-terminus binds to beta-catenin. However, previous studies have failed to fully explain the biological activities of beta-catenin. A study showing that nuclear translocation of beta-catenin results from the microinjection of XTcf-3 in embryos indicates that signaling by beta-catenin involves complete formation with XTcf-3 and the nuclear translocation and activation of specific XTcf-3 target genes.

Author: Oosterwegel, Mariette, Clevers, Hans, Wetering, Marc van de, Molenaar, Miranda, Peterson-Maduro, Josi, Godsave, Susan, Korinek, Vladimir, Roose, Jeroen, Destree, Oliver
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
Genetic aspects, Homology (Biology), Xenopus

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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

Article Abstract:

dTCF, a Drosophila gene which is a member of the family of transcription factors (T cell factor) was cloned and analyzed functionally using in situ hybridization, yeast two-hybrid and enzyme assays. The results confirmed that dTCF binds a canonical TCF DNA motif and interacts with beta-catenin homolog Armadillo. It was also found that dTCF forms a complex with Armadillo through which they act as bipartite transcription factor involved in the Wingless signaling pathway.

Author: Peifer, Mark, Clevers, Hans, Bejsovec, Amy, Jones, Tamara, Van de Wetering, Marc, Cavallo, Robert, Dooijes, Dennis, Van Beest, Moniek, Van Es, Johan, Loureiro, Joseph, Ypma, Arne, Hursh, Deborah, Mortin, Mark
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
Methods, Usage, In situ hybridization, Cloning, Drosophila, Enzymatic analysis

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Transcription factor target practice

Article Abstract:

Different ways of identifying direct targets of transcription factors and their corresponding regulatory sequences in the genome are studied. These studies provide an efficient way to decipher regulatory networks.

Author: Holstege, Frank C.P., Clevers, Hans
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
United States, Science & research, Nucleotide sequencing

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Subjects list: Research, Genetic transcription, Transcription (Genetics)
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