Zic2 patterns binocular vision by specifying the uncrossed retinal projection

Article Abstract:

Research demonstrates that the zinc finger transcription factor, Zic2, is expressed in the retinal ganglion cells and regulates the retinal ganglion cell axon repulsion at the optic chiasm midline. Data indicate that during central nervous system development, Zic2 expression determines the level of binocularity of vision in different species.

Author: Brown, Stephen, Mason, Carol A., Aruga, Jun, Mikoshiba, Katsuhiko, Herrera, Eloisa, Brown, Lucia, Rachel, Rivka A., Dolen, Gul
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
United States, Japan, Central nervous system, Cellular control mechanisms, Cell regulation, Vision research, Zinc finger proteins

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A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

Article Abstract:

Research shows that tyrosine phosphorylated alpha6beta4 integrin combines with adapter protein Shc and P13K leading to hepatocyte growth factor-triggered activation of Ras- and P13K-dependent pathways. Data suggest that the integrin helps cancer invasion by amplifying biochemical responses.

Author: Trusolino, Livio, Bertotti, Andrea, Comogilio, Paolo M.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Italy, Cellular signal transduction, Protein tyrosine kinase, Protein-tyrosine kinase, Cancer invasiveness, Integrins

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Subjects list: Physiological aspects
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